Si Woo Kim claimed his third PGA Tour title after winning The American Express 2021. Kim also won $1,206,000 from the total prize fund of $6,700,000. Here’s the prize money payout for each golfer at The American Express 2021:
| Position | Player | Prize money |
| 1 | Si Woo Kim | $1,206,000 |
| 2 | Patrick Cantlay | $730,300 |
| 3 | Cameron Davis | $462,300 |
| 4 | Tony Finau | $328,300 |
| T-5 | Abraham Ancer | $247,900 |
| T-5 | Michael Thompson | $247,900 |
| T-5 | Doug Ghim | $247,900 |
| T-8 | Ben An | $189,275 |
| T-8 | Paul Casey | $189,275 |
| T-8 | Francesco Molinari | $189,275 |
| T-8 | Brian Harman | $189,275 |
| T-12 | Henrik Norlander | $137,350 |
| T-12 | Rory Sabbatini | $137,350 |
| T-12 | Sungjae Im | $137,350 |
| T-12 | Chase Seiffert | $137,350 |
| T-16 | Bo Hoag | $102,175 |
| T-16 | Chris Kirk | $102,175 |
| T-16 | Ryan Armour | $102,175 |
| T-16 | Gary Woodland | $102,175 |
| T-16 | Russell Knox | $102,175 |
| T-21 | Kramer Hickok | $58,625 |
| T-21 | Branden Steele | $58,625 |
| T-21 | Rickie Fowler | $58,625 |
| T-21 | John Huh | $58,625 |
| T-21 | Brandon Hagy | $58,625 |
| T-21 | Andrew Putnam | $58,625 |
| T-21 | Luke List | $58,625 |
| T-21 | Talor Gooch | $58,625 |
| T-21 | Matt Jones | $58,625 |
| T-21 | Richy Werenski | $58,625 |
| T-21 | Max Homa | $58,625 |
| T-32 | Kyle Stanley | $38,257 |
| T-32 | James Hahn | $38,256 |
| T-32 | Kyoung-Hoon Lee | $38,257 |
| T-32 | Auastin Cook | $38,257 |
| T-32 | Adam Hadwin | $38,190 |
| T-37 | Bronson Burgoon | $31,257 |
| T-37 | Adam Schenk | $31,257 |
| T-37 | Emiliano Grillo | $31,257 |
| T-40 | Josh Teater | $25,125 |
| T-40 | Alex Noren | $25,125 |
| T-40 | Jamie Lovemark | $25,125 |
| T-40 | Rhein Gibson | $25,125 |
| T-40 | Matthew Wolff | $25,125 |
| T-40 | Roger Sloan | $25,125 |
| T-40 | Tyler McCumber | $25,125 |
| T-47 | Nick Taylor | $17,777.34 |
| T-47 | Rob Oppenheim | $17,777.34 |
| T-47 | Sam Ryder | $17,777.33 |
| T-47 | Martin Laird | $17,777.33 |
| T-47 | Brian Stuard | $17,777.33 |
| T-47 | Harry Hall | $17,777.33 |
| 53 | Patton Kizzire | $16,147 |
| T-54 | Charl Schwartzel | $15,812 |
| T-54 | Wyndham Clark | $15,812 |
| T-56 | Ben Martin | $15,410 |
| T-56 | Tyler Duncan | $15,410 |
| T-56 | Cameron Tringale | $15,410 |
| T-56 | Erik van Rooyen | $15,410 |
| T-60 | Jimmy Walker | $15,008 |
| T-60 | Vaughn Taylor | $15,008 |
| T-62 | Hank Lebioda | $14,740 |
| T-62 | Zach Johnson | $14,740 |
| T-64 | Andrew Landry | $14,338 |
| T-64 | David Hearn | $14,338 |
| T-64 | Will Gordon | $14,338 |
| T-64 | Sebastian Cappelen | $14,338 |
| 68 | Nelson Ledesma | $14,003 |
| 69 | Adam Long | $13,869 |
| 70 | Doc Redman | $13,735 |
| 71 | Maverick McNealy | $13,601 |