Jordan Spieth claimed his 12th PGA Tour title after winning the 2021 Valero Texas Open. Spieth also will take $1,386,000 from the total prize fund. Here’s the prize money payout for each golfer at the 2021 Valero Texas Open:
| Position | Player | Prize money |
| 1 | Jordan Spieth | $1,386,000 |
| 2 | Charley Hoffman | $839,300 |
| 3 | Matt Wallace | $531,300 |
| 4 | Lucas Glover | $377,300 |
| 5 | Anirban Lahiri | $315,700 |
| T6 | Chris Kirk | $259,875 |
| T6 | Brandt Snedeker | $259,875 |
| T6 | Gary Woodland | $259,875 |
| T9 | Patton Kizzire | $209,825 |
| T9 | Sebastián Muñoz | $209,825 |
| T9 | Cameron Tringale | $209,825 |
| T12 | Tom Hoge | $171,325 |
| T12 | Matt Kuchar | $171,325 |
| T14 | Corey Conners | $140,525 |
| T14 | Kyle Stanley | $140,525 |
| T14 | Erik van Rooyen | $140,525 |
| T17 | Rickie Fowler | $105,875 |
| T17 | Brandon Hagy | $105,875 |
| T17 | Luke List | $105,875 |
| T17 | Keith Mitchell | $105,875 |
| T17 | Ryan Palmer | $105,875 |
| T17 | Camilo Villegas | $105,875 |
| T23 | Abraham Ancer | $65,285 |
| T23 | Keegan Bradley | $65,285 |
| T23 | Branden Grace | $65,285 |
| T23 | Chesson Hadley | $65,285 |
| T23 | Adam Hadwin | $65,285 |
| T23 | Si Woo Kim | $65,285 |
| T23 | Kyoung-Hoon Lee | $65,285 |
| T30 | K.J. Choi | $49,280 |
| T30 | Martin Laird | $49,280 |
| T30 | Hideki Matsuyama | $49,280 |
| T30 | Rory Sabbatini | $49,280 |
| T34 | Joseph Bramlett | $36,036 |
| T34 | Rafael Campos | $36,036 |
| T34 | Cameron Champ | $36,036 |
| T34 | Lanto Griffin | $36,036 |
| T34 | Ben Martin | $36,036 |
| T34 | Denny McCarthy | $36,036 |
| T34 | Troy Merritt | $36,036 |
| T34 | Matthew NeSmith | $36,036 |
| T34 | Bo Van Pelt | $36,036 |
| T34 | Vincent Whaley | $36,036 |
| T44 | Rafa Cabrera Bello | $21,852.60 |
| T44 | Tyler Duncan | $21,852.60 |
| T44 | Sam Fidone | $21,852.60 |
| T44 | Doug Ghim | $21,852.60 |
| T44 | Kelly Kraft | $21,852.60 |
| T44 | Doc Redman | $21,852.60 |
| T44 | Chase Seiffert | $21,852.60 |
| T44 | Vaughn Taylor | $21,852.60 |
| T44 | Martin Trainer | $21,852.60 |
| T44 | Aaron Wise | $21,852.60 |
| T54 | Tom Lewis | $17,941 |
| T54 | Graeme McDowell | $17,941 |
| T54 | Seung-Yul Noh | $17,941 |
| T54 | Scottie Scheffler | $17,941 |
| T54 | Kevin Stadler | $17,941 |
| T59 | Sebastian Cappelen | $16,940 |
| T59 | Sung Kang | $16,940 |
| T59 | Tain Lee | $16,940 |
| T59 | Greyson Sigg | $16,940 |
| T59 | Scott Stallings | $16,940 |
| T59 | Nick Taylor | $16,940 |
| T59 | D.J. Trahan | $16,940 |
| T59 | Jimmy Walker | $16,940 |
| T67 | Pat Perez | $16,170 |
| T67 | Sepp Straka | $16,170 |
| T69 | Cameron Davis | $15,631 |
| T69 | Padraig Harrington | $15,631 |
| T69 | Beau Hossler | $15,631 |
| T69 | John Huh | $15,631 |
| T69 | Charl Schwartzel | $15,631 |
| 74 | Joel Dahmen | $15,169 |
| 75 | Kris Ventura | $15,015 |
| 76 | Ryan Moore | $14,861 |
| 77 | Brendan Steele | $14,707 |
| 78 | Will Gordon | $14,553 |