Garrick Higgo claimed his maiden PGA Tour title and a cheque for $1,314,000 after winning the 2021 Palmetto Championship at Congaree. Here’s the prize money payout for each golfer at the 2021 Palmetto Championship:
| Position | Player | Prize money |
| 1 | Garrick Higgo | $1,314,000 |
| T2 | Doc Redman | $411,233.34 |
| T2 | Hudson Swafford | $411,233.34 |
| T2 | Chesson Hadley | $411,233.33 |
| T2 | Tyrrell Hatton | $411,233.33 |
| T2 | Bo Van Pelt | $411,233.33 |
| T2 | Jhonattan Vegas | $411,233.33 |
| T8 | Ryan Armour | $220,825 |
| T8 | David Lipsky | $220,825 |
| T10 | Matt Fitzpatrick | $177,025 |
| T10 | Dustin Johnson | $177,025 |
| T10 | Pat Perez | $177,025 |
| T10 | Erik van Rooyen | $177,025 |
| T14 | Harris English | $125,925 |
| T14 | Will Gordon | $125,925 |
| T14 | Tain Lee | $125,925 |
| T14 | Wilco Nienaber | $125,925 |
| T14 | Chez Reavie | $125,925 |
| T19 | Beau Hossler | $86,505 |
| T19 | Satoshi Kodaira | $86,505 |
| T19 | Danny Lee | $86,505 |
| T19 | Rob Oppenheim | $86,505 |
| T19 | Scott Piercy | $86,505 |
| T19 | Seamus Power | $86,505 |
| T25 | Anirban Lahiri | $56,088.34 |
| T25 | Henrik Norlander | $56,088.34 |
| T25 | Joseph Bramlett | $56,088.33 |
| T25 | Rhein Gibson | $56,088.33 |
| T25 | Bill Haas | $56,088.33 |
| T25 | Ian Poulter | $56,088.33 |
| T31 | Austin Cook | $44,621.25 |
| T31 | Luke Donald | $44,621.25 |
| T31 | Hank Lebioda | $44,621.25 |
| T31 | C.T. Pan | $44,621.25 |
| T35 | Tommy Fleetwood | $33,336.67 |
| T35 | Sungjae Im | $33,336.67 |
| T35 | Russell Knox | $33,336.67 |
| T35 | Matthew NeSmith | $33,336.67 |
| T35 | Chase Seiffert | $33,336.67 |
| T35 | Davis Thompson | $33,336.67 |
| T35 | Broc Everett | $33,336.66 |
| T35 | Bryson Nimmer | $33,336.66 |
| T35 | Ben Taylor | $33,336.66 |
| T44 | Aaron Baddeley | $22,435.34 |
| T44 | Peter Uihlein | $22,435.34 |
| T44 | Kevin Chappell | $22,435.33 |
| T44 | Scott Harrington | $22,435.33 |
| T44 | Wes Roach | $22,435.33 |
| T44 | Nick Taylor | $22,435.33 |
| T50 | J.B. Holmes | $18,542 |
| T50 | Patrick Rodgers | $18,542 |
| T52 | Byeong Hun An | $17,483.50 |
| T52 | Sam Ryder | $17,483.50 |
| T52 | Roger Sloan | $17,483.50 |
| T52 | Vaughn Taylor | $17,483.50 |
| 56 | Rafael Campos | $17,009 |
| T57 | Jonathan Byrd | $16,717 |
| T57 | Mark Hubbard | $16,717 |
| T57 | Robby Shelton | $16,717 |
| T60 | Chris Baker | $16,279 |
| T60 | Tyler Duncan | $16,279 |
| T60 | Brandt Snedeker | $16,279 |
| 63 | Josh Teater | $15,987 |
| T64 | Robert Garrigus | $15,768 |
| T64 | Michael Gellerman | $15,768 |
| 66 | Richard S. Johnson | $15,549 |
| 67 | Andrew Putnam | $15,403 |
| 68 | Adam Schenk | $15,257 |