Sam Burns claimed his second PGA Tour title and a cheque for $1,260,000 after winning the 2021 Sanderson Farms Championship. Here’s the prize money payout for each golfer at the 2021 Sanderson Farms Championship:
| Position | Player | Earned money | Per shot |
| 1 | Sam Burns | $1,260,000 | $4,736.84 |
| T2 | Nick Watney | $623,000 | $2,333.33 |
| T2 | Cameron Young | $623,000 | $2,333.33 |
| T4 | Hayden Buckley | $280,000 | $1,044.78 |
| T4 | Andrew Landry | $280,000 | $1,044.78 |
| T4 | Trey Mullinax | $280,000 | $1,044.78 |
| T4 | Henrik Norlander | $280,000 | $1,044.78 |
| T8 | Si Woo Kim | $204,750 | $761.15 |
| T8 | Seth Reeves | $204,750 | $761.15 |
| T8 | Sahith Theegala | $204,750 | $761.15 |
| T11 | Cheng-Tsung Pan | $162,750 | $602.78 |
| T11 | Cameron Tringale | $162,750 | $602.78 |
| T11 | Harold Varner III | $162,750 | $602.78 |
| T14 | Tyler Duncan | $127,750 | $471.40 |
| T14 | Roger Sloan | $127,750 | $471.40 |
| T14 | Will Zalatoris | $127,750 | $471.40 |
| T17 | Corey Conners | $86,683 | $318.69 |
| T17 | Nate Lashley | $86,683 | $318.69 |
| T17 | Luke List | $86,683 | $318.69 |
| T17 | Denny McCarthy | $86,683 | $318.69 |
| T17 | William McGirt | $86,683 | $318.69 |
| T17 | Taylor Moore | $86,683 | $318.69 |
| T17 | Brendan Steele | $86,683 | $318.69 |
| T17 | Matthew Wolff | $86,683 | $318.69 |
| T17 | Grant Hirschman | $86,683 | $318.69 |
| T26 | Nick Hardy | $54,250 | $198.72 |
| T26 | Stephan Jaeger | $54,250 | $198.72 |
| T26 | Aaron Wise | $54,250 | $198.72 |
| T29 | Russell Knox | $49,000 | $178.83 |
| T29 | Adam Long | $49,000 | $178.83 |
| T31 | Sung-jae Im | $42,788 | $155.59 |
| T31 | Mito Pereira | $42,788 | $155.59 |
| T31 | Alex Smalley | $42,788 | $155.59 |
| T31 | Kevin Streelman | $42,788 | $155.59 |
| T35 | Mackenzie Hughes | $35,613 | $129.03 |
| T35 | Chris Kirk | $35,613 | $129.03 |
| T35 | Davis Thompson | $35,613 | $129.03 |
| T35 | Kyle Reifers | $35,613 | $129.03 |
| T39 | Paul Barjon | $28,350 | $102.35 |
| T39 | Dylan Frittelli | $28,350 | $102.35 |
| T39 | Emiliano Grillo | $28,350 | $102.35 |
| T39 | Charley Hoffman | $28,350 | $102.35 |
| T39 | Ryan Moore | $28,350 | $102.35 |
| T39 | Taylor Pendrith | $28,350 | $102.35 |
| T45 | Chesson Hadley | $20,846 | $74.99 |
| T45 | Adam Hadwin | $20,846 | $74.99 |
| T45 | Lee Hodges | $20,846 | $74.99 |
| T45 | Kurt Kitayama | $20,846 | $74.99 |
| T45 | Jimmy Walker | $20,846 | $74.99 |
| T45 | Eugenio Chacarra (a) | 0 | $0.00 |
| T51 | Joel Dahmen | $17,234 | $61.77 |
| T51 | Peter Malnati | $17,234 | $61.77 |
| T51 | Andy Ogletree | $17,234 | $61.77 |
| T51 | Sam Ryder | $17,234 | $61.77 |
| T51 | Michael Thompson | $17,234 | $61.77 |
| T56 | Brice Garnett | $16,380 | $58.50 |
| T56 | Doc Redman | $16,380 | $58.50 |
| T58 | Joseph Bramlett | $15,890 | $56.55 |
| T58 | Doug Ghim | $15,890 | $56.55 |
| T58 | Lucas Glover | $15,890 | $56.55 |
| T58 | Brandon Hagy | $15,890 | $56.55 |
| T58 | Andrew Novak | $15,890 | $56.55 |
| T63 | John Huh | $15,400 | $54.61 |
| T63 | Chad Ramey | $15,400 | $54.61 |
| T65 | Sung-Hoon Kang | $15,120 | $53.43 |
| T65 | Vincent Whaley | $15,120 | $53.43 |
| 67 | Austin Cook | $14,910 | $52.50 |
| 68 | J.J. Spaun | $14,770 | $51.46 |