Branden Grace claimed his second PGA Tour title at the 2021 Puerto Rico Open. The South African also won $540,000 from tournament’s prize fund of $3,000,000. Here’s the prize money payout for each golfer at the 2021 Puerto Rico Open:
| Position | Player | Prize money |
| 1 | Branden Grace | $540,000 |
| 2 | Jhonattan Vegas | $327,000 |
| T3 | Rafael Campos | $177,000 |
| T3 | Grayson Murray | $177,000 |
| T5 | Brice Garnett | $115,875 |
| T5 | Andrew Putnam | $115,875 |
| T7 | Rob Oppenheim | $91,125 |
| T7 | Cameron Percy | $91,125 |
| T7 | Ted Potter Jr. | $91,125 |
| T7 | Brandon Wu | $91,125 |
| T11 | Ryan Brehm | $72,750 |
| T11 | Emiliano Grillo | $72,750 |
| T13 | Lee Hodges | $60,750 |
| T13 | Wes Roach | $60,750 |
| T15 | Fabián Gómez | $45,750 |
| T15 | Joohyung Kim | $45,750 |
| T15 | Nelson Ledesma | $45,750 |
| T15 | Thomas Pieters | $45,750 |
| T15 | Chase Seiffert | $45,750 |
| T15 | Bo Van Pelt | $45,750 |
| T15 | Vincent Whaley | $45,750 |
| T22 | Greg Chalmers | $28,950 |
| T22 | Seamus Power | $28,950 |
| T22 | Roger Sloan | $28,950 |
| T22 | Josh Teater | $28,950 |
| T22 | D.J. Trahan | $28,950 |
| T27 | Will Gordon | $22,350 |
| T27 | Adam Schenk | $22,350 |
| T27 | Tim Wilkinson | $22,350 |
| T30 | Aaron Baddeley | $18,780 |
| T30 | Bill Haas | $18,780 |
| T30 | Patrick Rodgers | $18,780 |
| T30 | Andres Romero | $18,780 |
| T30 | Xinjun Zhang | $18,780 |
| T35 | Byeong Hun An | $15,262.50 |
| T35 | Charlie Beljan | $15,262.50 |
| T35 | Ian Poulter | $15,262.50 |
| T35 | Justin Suh | $15,262.50 |
| T39 | Bronson Burgoon | $10,962 |
| T39 | Jonathan Byrd | $10,962 |
| T39 | Roberto Castro | $10,962 |
| T39 | Lucas Glover | $10,962 |
| T39 | Anirban Lahiri | $10,962 |
| T39 | Bryson Nimmer | $10,962 |
| T39 | Davis Riley | $10,962 |
| T39 | Sam Ryder | $10,962 |
| T39 | Vaughn Taylor | $10,962 |
| T39 | Peter Uihlein | $10,962 |
| T49 | Jason Bohn | $7,635 |
| T49 | Joseph Bramlett | $7,635 |
| T49 | Satoshi Kodaira | $7,635 |
| T49 | Kristoffer Ventura | $7,635 |
| T53 | Ryan Blaum | $7,062 |
| T53 | Scott Brown | $7,062 |
| T53 | David Lingmerth | $7,062 |
| T53 | Taylor Pendrith | $7,062 |
| T53 | Dalton Ward | $7,062 |
| T58 | Paul Barjon | $6,750 |
| T58 | Edward Figueroa | $6,750 |
| T58 | Michael Gellerman | $6,750 |
| T58 | Padraig Harrington | $6,750 |
| T58 | Stephan Jaeger | $6,750 |
| T63 | Mark Anderson | $6,510 |
| T63 | Michael Gligic | $6,510 |
| T63 | Dylan Meyer | $6,510 |
| T66 | Will Cannon | $6,360 |
| T66 | Zack Sucher | $6,360 |
| T68 | Tommy Gainey | $6,150 |
| T68 | Richard S. Johnson | $6,150 |
| T68 | George McNeill | $6,150 |
| T68 | Marcelo Rozo | $6,150 |
| T68 | J.J. Spaun | $6,150 |
| 73 | Ben Martin | $5,970 |
| 74 | Michael Kim | $5,910 |
| 75 | John Senden | $5,850 |