Jason Kokrak claimed his third PGA Tour title and a cheque for $1,350,000 after winning the 2021 Houston Open. Here’s the prize money payout for each golfer at the 2021 Houston Open:
| Position | Player | Earned money | Per shot |
| 1 | Jason Kokrak | $1,350,000 | $5,000 |
| T2 | Kevin Tway | $667,500 | $2,454 |
| T2 | Scottie Scheffler | $667,500 | $2,454 |
| 4 | Kramer Hickok | $367,500 | $1,346 |
| T5 | Joel Dahmen | $289,688 | $1,057 |
| T5 | Martin Trainer | $289,688 | $1,057 |
| T7 | Robert Streb | $227,813 | $828 |
| T7 | Sam Burns | $227,813 | $828 |
| T7 | Cameron Tringale | $227,813 | $828 |
| T7 | Russell Henley | $227,813 | $828 |
| T11 | Denny McCarthy | $166,875 | $605 |
| T11 | Adam Long | $166,875 | $605 |
| T11 | Luke List | $166,875 | $605 |
| T11 | Matthew Wolff | $166,875 | $605 |
| T15 | Alex Smalley | $125,625 | $454 |
| T15 | Hank Lebioda | $125,625 | $454 |
| T15 | Cameron Smith | $125,625 | $454 |
| T15 | Vincent Whaley | $125,625 | $454 |
| T19 | Sung-jae Im | $85,661 | $308 |
| T19 | Scott Piercy | $85,661 | $308 |
| T19 | Aaron Rai | $85,661 | $308 |
| T19 | Dylan Frittelli | $85,661 | $308 |
| T19 | Maverick McNealy | $85,661 | $308 |
| T19 | Max McGreevy | $85,661 | $308 |
| T19 | Marc Leishman | $85,661 | $308 |
| T26 | Aaron Wise | $58,125 | $208 |
| T26 | Ryan Palmer | $58,125 | $208 |
| T26 | Jhonattan Vegas | $58,125 | $208 |
| T29 | Tyler Duncan | $48,063 | $172 |
| T29 | Mito Pereira | $48,063 | $172 |
| T29 | Mackenzie Hughes | $48,063 | $172 |
| T29 | Davis Riley | $48,063 | $172 |
| T29 | Kelly Kraft | $48,063 | $172 |
| T29 | Adam Schenk | $48,063 | $172 |
| T35 | Bronson Burgoon | $36,563 | $130 |
| T35 | Max Homa | $36,563 | $130 |
| T35 | Stephan Jaeger | $36,563 | $130 |
| T35 | Chris Stroud | $36,563 | $130 |
| T35 | Hudson Swafford | $36,563 | $130 |
| T35 | Matthias Schwab | $36,563 | $130 |
| T41 | Nick Taylor | $28,125 | $100 |
| T41 | Andrew Putnam | $28,125 | $100 |
| T41 | Keith Mitchell | $28,125 | $100 |
| T41 | Chez Reavie | $28,125 | $100 |
| T41 | Wyndham Clark | $28,125 | $100 |
| T46 | Matthew NeSmith | $21,638 | $76 |
| T46 | J.J. Spaun | $21,638 | $76 |
| T46 | Tom Hoge | $21,638 | $76 |
| T46 | Lee Hodges | $21,638 | $76 |
| T50 | Brice Garnett | $18,638 | $66 |
| T50 | Harry Higgs | $18,638 | $66 |
| T50 | Kevin Streelman | $18,638 | $66 |
| T50 | Richy Werenski | $18,638 | $66 |
| T54 | Jason Day | $17,400 | $61 |
| T54 | Jim Herman | $17,400 | $61 |
| T54 | Erik Van Rooyen | $17,400 | $61 |
| T54 | Brian Harman | $17,400 | $61 |
| T54 | Adam Scott | $17,400 | $61 |
| T54 | Zach Johnson | $17,400 | $61 |
| 60 | Talor Gooch | $16,875 | $59 |
| T61 | Scott Stallings | $16,575 | $58 |
| T61 | Sahith Theegala | $16,575 | $58 |
| T61 | Patrick Reed | $16,575 | $58 |
| T64 | Lanto Griffin | $16,200 | $56 |
| T64 | MJ Daffue | $16,200 | $56 |
| 66 | Brian Stuard | $15,975 | $55 |
| 67 | Henrik Norlander | $15,825 | $55 |